Description
Prostaglandin J
2-d
4 is intended for use as an internal standard for the quantification of prostaglandin J
2 by GC- or LC-MS. Prostaglandin J
2 (PGJ
2) is formed from PGD
2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.
1 PGJ
2 inhibits platelet aggregation with an IC
50 of about 5-10 nM.
2,3 PGJ
2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.
4 However, this activity has been attributed to further metabolites of PGJ
2 and not the parent compound itself.
References
1. Fitzpatrick, F.A., and Wynalda, M.A. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro J. Biol. Chem. 258(19),11713-11718(1983).
2. Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues J. Med. Chem. 26(6),790-799(1983).
3. Mahmud, I., Smith, D.L., Whyte, M.A., et al. On the identification and biological properties of prostaglandin J2 Prostaglandins Leukot. Med. 16(2),131-146(1984).
4. Fukushima, M. Prostaglandin J2 - anti-tumor and anti-viral activities and the mechanisms involved Eicosanoids 3(4),189-199(1990).
