8-pCPT-cGMP-AM (8-(4-Chlorophenylthio)-cGMP-AM) is a highly membrane permeable prodrug of the PKG agonist 8-pCPT-cGMP, which increases the membrane permeability of cGMP and is converted to its active form by esterase hydrolysis within the cell, thereby activating PKG. 8-pCPT-cGMP-AM can be used to explore the role of cGMP signaling in neural plasticity and memory formation[1].
References
[1] Butt E. cGMP-dependent protein kinase modulators[J]. cGMP: Generators, Effectors and Therapeutic Implications, 2009: 409-421. DOI:10.1007/978-3-540-68964-5_17
