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PET-cGMP is a cyclic guanosine monophosphate analog and an effective selective agonist of PKG I, the EC50 of PET-cGMP for PKG Iβ is 3.8 nM, while for PKG II, it's 193 nM[1].

cGMP-dependent protein kinase (PKG I and PKG II) activator. Potent membrane permeant activator of both isozymes I α and I β of cGMP-dependent protein kinase. Common stimulators such as 8-Br-cGMP or 8-pCPT-cGMP mainly activate kinase subtype Iα.

[1] James C Campbell, et al. Structural Basis of Analog Specificity in PKG I and II. ACS Chem Biol. 2017 Sep 15;12(9):2388-2398. DOI:10.1021/acschembio.7b00369