ChemicalBook CAS DataBase List 2714434-21-4

2714434-21-4

Name	IAG933
CAS	2714434-21-4
Molecular Formula	C27H26ClF2N3O4
Molecular Weight	529.96
MOL File	2714434-21-4.mol

Chemical Properties

Boiling point	626.125±55.00 °C(Press: 760.00 Torr)(predicted)
density	1.367±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
form	Solid
pka	13.275±0.46(predicted)
color	White to off-white
InChIKey	HUVOYQMXUNTUAI-UHFFFAOYSA-N
SMILES	ClC1=C(C=C2C(=C1C1=C(C(=NC=C1C(=O)NC)OCCO)F)CC(C1C=CC=CC=1)(C1NCCC1)O2)F

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Animal Model:	Mouse MSTO-211H cell-derived xenograft (CDX) model; mouse NCI-H226 cell-derived xenograft (CDX) model^[2]
Dosage:	30, 60, 120, 240 mg/kg, single dose; 70, 210 mg/kg, once daily, 28 days
Administration:	i.g.
Result:	Had a short half-life in mice, inhibiting the transcription of TEAD in the body, promoting apoptosis, and lowering the expression of BCL2L1 and MCL1. Led to tumor regression and a decrease in Ki67 expression.

Animal Model:	A rat MSTO-211H xenograft model^[2]
Dosage:	3, 10, 30 mg/kg, once daily, 2 weeks
Administration:	i.g.
Result:	Showed the tumor stagnant at 10 mg/kg, and shrank at 30 mg/kg.

2714434-21-4

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in vivo

IC 50

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