10-PAHSA 13C4 is intended for use as an internal standard for the quantification of 10-PASHA (Item No. 19973) by GC- or LC-MS. 10-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid (Item No. 10006627) is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue.1 As other FAHFAs improve glucose tolerance, stimulate insulin secretion, and have anti-inflammatory effects, 10-PAHSA may be a bioactive lipid with roles in metabolic syndrome and inflammation.WARNING This product is not for human or veterinary use.
References
[1] MARK M YORE. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.[J]. Cell, 2014, 159 2: 318-332. DOI: 10.1016/j.cell.2014.09.035
