Description
10(S)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue. A study using synthesized (R)- and (S)- stereoisomers of 9-PAHSA reported that the 9(R)-PAHSA is the predominant form that accumulates in adipose tissues in vivo. Also, cell lines favor the production of 9(R)-PAHSA and carboxyl ester lipase selectively hydrolyzes 9(S)-PAHSA .The use of this optically-active FAHFA product (the “Product”) is covered by U.S. Patent No. 10,240,025 and corresponding foreign counterpart applications. These patents and applications are licensed by Cayman pursuant to an agreement with BT Food, Drug and Personal Care, LLC, and this Product is sold exclusively for research and development purposes only. Product may not be used for human studies, veterinary use or diagnostics, clinical trial work, clinical diagnostics, or any other clinical trial or approval activities related to humans or animals. This limited label license does not grant any right to use the Product or a Product derivative in commercial products or services. This Product may not be re-sold, distributed, or repackaged unless by official Cayman distributors. For information on commercial rights, please contact the outlicensing department at jforest@biosynthetic.com.
References
[1] PEDRO M MORAES-VIEIRA Barbara B K Alan Saghatelian. GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects.[J]. Diabetes, 2016: 1808-1815. DOI:
10.2337/db16-0221[2] ANDREW T. NELSON. Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation[J]. Journal of the American Chemical Society, 2017, 139 13: 4943-4947. DOI:
10.1021/jacs.7b01269
