Description
Hexadecanal-d
5 is intended for use as an internal standard for the quantification of hexadecanal by GC- or LC-MS. Sphingosine-1-phosphate (S1P) is a potent bioactive phospholipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.
1 Hexadecanal is the 16-carbon aldehyde analog of palmitic acid. It is produced from the irreversible cleavage of S1P by S1P lyase 1 and is a major component of plasmalogen.
2,3
References
1. Leclercq, T.M., and Pitson, S.M. Cellular signalling by sphingosine kinase and sphingosine 1-phosphate IUBMB Life 58(8),467-472(2006).
2. Reiss, U., Oskouian, B., Zhou, J., et al. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis J. Biol. Chem. 279(2),1281-1290(2004).
3. Pyne, S., and Pyne, N.J. Sphingosine 1-phosphate signalling in mammalian cells Biochem. J. 349(Pt 2),385-402(2000).
