27007-85-8

Name	Spiclomazine
CAS	27007-85-8
Molecular Formula	C22H25Cl2N3OS2
MDL Number	MFCD01681961
Molecular Weight	482.48
MOL File	27007-85-8.mol

Synonyms

Apy 606 Diceplon Disepron Nsc290956 Spiclomazine HCl Spiclomazine Hydrochloride Clospirazine hydrochloride 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-[3-(2-chlorophenothiazin-10-yl)propyl]-, monohydrochloride 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-, monohydrochloride

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Chemical Properties

Melting point

262-264° (dec)

Safety Data

Toxicity

LD50 in mice, rats (mg/kg): 3400, 2950 i.p.; >5490, >5490 s.c.; 3800, 4000 orally (Nakanishi, 1970)

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Hazard Information

Uses

Spiclomazine hydrochloride (APY-606) is an antipsychotic and antitumor agent. Spiclomazine hydrochloride inhibits KRas. Spiclomazine hydrochloride induces cancer cell apoptosis[1][2].

Definition

ChEBI: Clospirazine hydrochloride is a member of phenothiazines.

in vivo

Spiclomazine (68 mg/kg; i.p.; every other day for two weeks) hydrochloride reduces the growth of MIA PaCa-2 xenograft in mice^[2].

Animal Model:	BALB/c mice, MIA PaCa-2 xenograft model^[2]
Dosage:	68 mg/kg
Administration:	Intraperitoneal injection, every other day for two weeks
Result:	Completely blocked the growth of tumors in three of the five mice.

IC 50

K-RAS

References

[1] Zhao W, et al. Spiclomazine induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells. PLoS One. 2013 Jun 20;8(6):e66362. DOI:10.1371/journal.pone.0066362
[2] Guo X, et al. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9(6):6938-6951. DOI:10.18632/oncotarget.24025

Supplier

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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