26598-44-7

Ethybenztropine hydrochloride (Ponalid hydrochloride) is an anticholinergic drug with antiparkinsonian activity. Ethybenztropine hydrochloride may also have dopamine reuptake inhibitory effects. Ethybenztropine hydrochloride is used to improve motor symptoms in patients with Parkinson's disease. Ethybenztropine hydrochloride exerts its inhibitory effects by regulating the balance of neurotransmitters[1].

[1] A K Saxena, et al. Presence of cholinoceptors in mesencephalic raphe nuclei concerned in thermoregulation in rabbits. Clin Exp Pharmacol Physiol. 1984 Mar-Apr;11(2):105-10. DOI:10.1111/j.1440-1681.1984.tb00247.x
[2] Effects of intracerebroventricular l-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside DOI:10.1016/0028-3908(68)90048-8
[3] M Rozear, et al. Effects of intracerebroventricular l-hyoscyamine, ethybenztropine and procaine on cardiac arrhythmias induced in dogs by pentylenetetrazol, picrotoxin or deslanoside. Int J Neuropharmacol. 1968 Jan;7(1):1-6. DOI:10.1016/0028-3908(68)90048-8
[4] LARS-OVE FARNEBO, et al. Effect of some antiparkinsonian drugs on catecholamine neurons. Journal of Pharmacy and Pharmacology, 1970, 22(10): 733-737.