2650530-00-8

SGC-STK17B-1 is a potent and selective inhibitor of STK17B/DRAK2 kinase.

SGC-STK17B-1 is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC50: 34 nM, KD: 5.6 nM)[1].

ChEBI: {[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanyl}acetic acid is a thienopyrimidine that is thieno[3,2-d]pyrimidine which is substituted by a (carboxymethyl)sulfanediyl group at position 4 and by a 1-benzothiophen-2-yl group at position 6. It is a STK17B kinase inhibitor. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a thienopyrimidine, a sulfur-containing carboxylic acid, a monocarboxylic acid, an aryl sulfide, a member of 1-benzothiophenes and a biaryl.

[1] Picado A, et al. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem. 2020 Dec 10;63(23):14626-14646. DOI:10.1021/acs.jmedchem.0c01174