ChemicalBook CAS DataBase List 2647441-36-7

2647441-36-7

Name	D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-, 6-(2-methylpropanoate)
CAS	2647441-36-7
Molecular Formula	C16H19N5O5
Molecular Weight	361.36
MOL File	2647441-36-7.mol

Chemical Properties

density	1.59±0.1 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 250 mg/mL (691.85 mM; Need ultrasonic)
form	Solid
pka	12.00±0.70(Predicted)
color	White to off-white

Hazard Information

Uses

Obeldesivir (ATV006) is a potent, orally active antiviral agent and ester proagents of GS-441524. Obeldesivir inhibits the replication of SARS-CoV-2 and its variants. Obeldesivir can be used for SARS-CoV-2 research[1].

in vivo

Obeldesivir (5-25 mg/kg; p.o. and i.v.; Sprague Dawley rats) has favorable pharmacokinetic profiles in rats with high oral bioavailability (F %) of 81.5% and maximum blood concentration (C_max) of 8.2 μM^[1].
Obeldesivir (250-500 mg/kg; p.o.; daily, for 4 days; hACE2 knock-in and Ad5-hACE2 mice) has antiviral activity and inhibits SARS-CoV-2 replication in mouse models^[1].
Obeldesivir (100-250 mg/kg; p.o.; daily, for 10 days) reduces lung damage and protects K18-hACE2 mice^[1].
Obeldesivir (10-150 mg/kg; p.o.; daily, for 3 days) reduces virus titers and lung damage caused by Delta variant infection in K18-hACE2 mice^[1].

Animal Model:

Sprague Dawley rats^[1]

Dosage:

5 and 25 mg/kg

Administration:

Oral administration (25 mg/kg) and intravenous injection (5 mg/kg)

Result:

1.19

parameters	i.v. (5 mg/kg)	p.o. (25 mg/kg)
AUC_last (μM·h)	5.6	22.8
T_1/2 (h)	1.5	1.2
T_max (h)		0.5
C_max (μM)	8.7	8.2
F %		81.5

Animal Model:	hACE2 knock-in and Ad5-hACE2 mice^[1]
Dosage:	250 and 500 mg/kg
Administration:	Oral administration; daily, for 4 days
Result:	Inhibited gRNA and sgRNA, which is Biomarkers of coronavirus replication. Reduced the viral load and pathological damage of the lung.

Animal Model:	K18-hACE2 mice^[1]
Dosage:	100 and 250 mg/kg
Administration:	Oral administration; daily, for 10 days
Result:	Reduced viral RNA and increased the survival rate of mice. Reduced evidence of lung pathology and the production of inflammatory cytokines and chemokines in the lung tissues.

Animal Model:	K18-hACE2 mice^[1]
Dosage:	10, 30, 80 and 150 mg/kg
Administration:	Oral administration; daily, for 3 days
Result:	Reduced viral load in a dose-dependent manner and alleviated the symptoms in the lung.

References

[1] Cao L, et, al. The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants. Sci Transl Med. 2022 May 17:eabm7621. DOI:10.1126/scitranslmed.abm7621

Spectrum Detail

Supplier

Shanghai Synmedia Chemical Co., Ltd.

Telephone021-38681880 13817889927

Websitehttp://www.synmedia-chem.com

Shanghai Lollane Biological Technology Co.,Ltd.

Telephone021-52996696，15000506266 15000506266

Websitehttp://www.bioll.com

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Shanghai Rechem science Co., Ltd.

Telephone021-31433387 15618786686

Websitehttp://cn.rechemscience.com

Suzhou Rovathin Foreign Trade Co.,Ltd

Telephone0512-65816829 18662214788

Websitehttp://www.rovathin.com/

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Telephone63313187 15358055255

Websitehttp://www.cegchemical.com

Zhejiang Huida Biotech Co., LTD

Telephone0571-89903022 18679456698

Websitehttps://www.huidacollection.cn

Nantong Hi-Future Biotechnology Co., Ltd

Telephone+86-0513; 18051384581

Websitehttps://www.chemhifuture.com/

Bide Pharmatech Ltd.

Telephone400-1647117 13681763483

Websitehttps://www.bidepharm.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Shanghai Tachizaki Biomedical Research Center

Telephone 18014399201

Websitehttp://www.chemlab-tachizaki.com/

Wuhan Jingkangen Biomedical Technology Co., Ltd

Telephone13720134139 086-15871494362 13720134139

Websitehttps://www.jknbiochem.com

https://hanhongsci.com/

Telephone021-54306202 18917919676

Websitehttps://www.hanhongsci.com/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

Changsha Fuzhen Biotechnology Co.，LTD

Telephone15111215862 18229892877

Websitehttp://www.fuzhenbiochem.com/

Tianjin Xinkangyou Biotechnology Co., LTD

Telephone19922659386

Website

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

Olix ( Hubei) Pharmaceutical Technology Co., Ltd

Telephone17316404525 17316404525

Websitehttps://www.olix.cn

1of4

Related Products

Send Inquriy