26289-39-4

Light Yellow Solid

A substrate for Glutathione-S-Transferase, with a kinetically determined dissociation constant of 7uM

ChEBI: A Glu-Cys-Gly tripeptide glutathione conjugate containing a 2,4-dinitrophenyl substituent on the S of Cys.

S-(2,4-Dinitrophenyl)-glutathione is a substrate for glutathione-S-transferase with a kinetic dissociation constant of 7 μM. In vitro, it is transported by multidrug resistance protein 1 (MDR1) and MDR3, which are transporters that confer resistance to some chemotherapeutics.

[1] V L SCHRAMM. Kinetic studies and active site-binding properties of glutathione S-transferase using spin-labeled glutathione, a product analogue.[J]. The Journal of Biological Chemistry, 1984, 259 2: 714-722.
[2] H ZENG. Transport of amphipathic anions by human multidrug resistance protein 3.[J]. Cancer research, 2000, 60 17: 4779-4784.