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Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 - 10 μM resulted in moderate to very strong gr

Nimbolide exhibits anti-malarialanti-bacterialand anti-cancer activities. It has been shown to induce apoptosis in osteosarcoma cells and inhibits cell migration of these cells by modulating the expression of integrin αvβ5. In human renal carcinoma cellsnimbolide induced cell cycle arrestDNA damageand apoptosis.It has been shown to modulate autophagy and apoptosis in pancreatic cancer.

NF-κB; CDK4; CDK6

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