PXS-6302 inhibits LOX, reduces crosslinking and improves scar appearance in porcine models of excisional and burn injury[1].
PXS-6302 (1.5%, oil in water cream; 500 mg cream applied to 16 cm2; external application; once daily, for 28 days) reduces collagen deposition and cross-linkin in murine models of injury and fibrosis under topical application[1].
PXS-6302 (0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2; external application; once daily, for 12 weeks) also significantly improves scar appearance without reducing tissue strength in porcine injury models under topical application[1].
| Animal Model: | Porcine excision injury model (female Juvenile pigs, 18-20 kg)[1] |
| Dosage: | 0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2 |
| Administration: | External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks |
| Result: | Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance. |
