CHIR-98023 is a potent, selective and reversible inhibitor of GSK3, with IC50s of 10 nM and 6.7 nM for GSK3α and GSK3β, respectively. CHIR-98023 can improve insulin action and glucose metabolism[1][2].
IC 50
GSK3α: 10 nM (IC50); GSK3β: 6.7 nM (IC50)
References
[1] Cline GW, et, al. Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats. Diabetes. 2002 Oct;51(10):2903-10. DOI:10.2337/diabetes.51.10.2903 [2] Hu M, et, al. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells. J Neurochem. 2008 Aug;106(3):1371-7. DOI:10.1111/j.1471-4159.2008.05483.x
