ChemicalBook CAS DataBase List 25189-55-3

25189-55-3

Name	POLY(N-ISOPROPYL ACRYLAMIDE)
CAS	25189-55-3
Molecular Formula	C6H11NO
MDL Number	MFCD00284282
Molecular Weight	113.158
MOL File	25189-55-3.mol

Synonyms

PNIPAM nipam polymer POLY(N-ISOPROPYL ACRYLAMIDE) N-ISO-PROPYLACRYLAMIDE POLYMER Poly(N-isopropylacrylamide) (PNiPAM) Poly(N-isopropylacrylamide) Mn ~40,000 poly(N-isopropylacrylamide) macromolecule n-(1-methylethyl)-2-propenamidhomopolymer poly(n-iso-propylacrylamide)(mw20000-25000) N-(1-Methylethyl)-2-propenamide homopolymer Poly(N-isopropylacrylaMide) Mw 20,000-40,000 2-Propenamide,N-(1-methylethyl)-,homopolymer Poly(N-isopropylacrylamide) Mn 20,000-40,000 Poly(N-isopropylacrylamide) average Mn 30,000 2-Propenamid, N-(1-methylethyl)-, Homopolymer POLY(N-ISOPROPYL ACRYLAMIDE) ISO 9001：2015 REACH Poly(N-isopropylacrylaMide), carboxylic acid terMinated average Mn 10,000 Poly(N-isopropylacrylamide),NIPAM polymer, PNIPAM, Polyacrylamide, polyNIPAM 2-Propenamide, N-(1-methylethyl)-, homopolymer n-(1-methylethyl)-2-propenamid homopolymer

Chemical Properties

Melting point	96 °C(lit.)
density	1.386 g/cm3
Tg	130
storage temp.	-20°C
form	powder
color	white to off-white
InChI	InChI=1S/C6H11NO/c1-4-6(8)7-5(2)3/h4-5H,1H2,2-3H3,(H,7,8)
InChIKey	QNILTEGFHQSKFF-UHFFFAOYSA-N
SMILES	C(NC(C)C)(=O)C=C
EPA Substance Registry System	2-Propenamide, N-(1-methylethyl)-, homopolymer (25189-55-3)

Safety Data

WGK Germany	1
TSCA	TSCA listed

Hazard Information

Chemical Properties

mp 96°C phase transitions at 32°C to insoluble phase

Uses

PolyNIPAM is a stimuli-responsive polymer. The low PDI means that the distribution of chain lengths is narrow which will typically lead to better reproducibility. This polymer for development of thermosensitive coated micro/nano materials including thermoresponsive polymeric drug delivery systems. The carboxylic acid functional group can be used to conjugate a variety of biomolecules to the polymer chain.

Uses

Poly(N-iso-propyl acrylaMide) can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.

Definition

ChEBI: An acrylic macromolecule, arising from poymerisation of N-isopropylamide.

General Description

Poly(N-isopropylacrylamide) (PNIPAM) is a temperature-responsive polymer used in biomedical research applications. PNIPAM undergoes a reversible, lower critical solution temperature (LCST) phase transition when heated above 32 °C, transitioning from a soluble to an insoluble material. PNIPAM is also frequently crosslinked to yield hydrogels with reversible, thermal shrinking and swelling. Poly(N-isopropylacrylamide) is also readily functionalized and has been used as the hydrophilic block in the synthesis of thermoresponsive, amphiphilic block copolymers. Due to the similarity in temperature between the LCST of PNIPAM and the temperature of the human body, PNIPAM materials have been frequently utilized in tissue engineering and controlled drug delivery research applications.

Solubility in organics

Acetone, THF, water (cold)

Spectrum Detail

Supplier

Jinan Ruiyao Mingzhi Medical Technology Co., Ltd

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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Shanghai Wanna Juhe Polymer Technology Co., Ltd

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Rhawn Reagent

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Tianjin heowns Biochemical Technology Co., Ltd.

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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Beijing OKA biological technology co., LTD

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