ChemicalBook CAS DataBase List 2499962-58-0

2499962-58-0

Name	7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-6-(trifluoromethyl)-
CAS	2499962-58-0
Molecular Formula	C17H15F3N4
Molecular Weight	332.32
MOL File	2499962-58-0.mol

Chemical Properties

density	1.422±0.06 g/cm3(Predicted)
solubility	DMSO: Sparingly soluble: 1-10 mg/ml
form	Solid
pka	10.59±0.50(Predicted)
color	White to yellow

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Animal Model:	Stratum of mice injected with α-synuclein preformed fibrils (PFFs)^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage (p.o.), daily, 6 months
Result:	Rescued an activity deficit in freely moving PFF mice. Reduced the levels of inflammatory markers (TREM2, IL-6, and CXCL1).

Animal Model:	C57BL6J wildtype mice injected with PFF ^[1]
Dosage:	50 mg/kg
Administration:	Oral gavage (p.o.); 7 days, 3 weeks
Result:	Decreased pUb in the brain and plasma of PFF seeded mice.

2499962-58-0

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