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BAMEA-O16B is a disulfide bond-containing ionizable cationic lipid.¹ It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro and in vivo. LNPs containing BAMEA-O16B encapsulating Cas9 mRNA and sgRNAs targeting the gene encoding proprotein convertase subtilisin kexin type 9 (PCSK9) accumulate in the liver and decrease serum PCSK9 levels in mice.

1. Liu, J., Chang, J., Jiang, Y., et al. Fast and efficient CRISPR/Cas9 genome editing in vivo enabled by bioreducible lipid and messenger RNA nanoparticles Adv. Mater. 31(33),e1902575(2019).