2470229-60-6

Oxamyl-d6 is intended for use as an internal standard for the quantification of oxamyl (Item No. 25609) by GC- or LC-MS. Oxamyl is a carbamate pesticide and an inhibitor of acetylcholinesterase (AChE; IC50 = 1.67 μM for the C. gigas enzyme).1 It is nematocidal, decreasing the number of P. penetrans and M. hapla per gram of alfalfa (M. sativa) root when applied to seeds at a concentration of 50 mg/ml.2 Oxamyl (50 and 100 μg/ml) is also toxic to citrus nematode (T. semipenetrans) larvae.3 In vivo, oxamyl (2.1 and 3.5 mg/kg) inhibits plasma and brain AChE, as well as liver glucose-6-phosphatase and mitochondrial complex II, also known as succinate dehydrogenase, and reduces body weight gain in rats.4 Formulations containing oxamyl have been used to control nematode infestation of field crops.WARNING This product is not for human or veterinary use.

[1] GERARDO A. ANGUIANO. Effects of exposure to oxamyl, carbofuran, dichlorvos, and lindane on acetylcholinesterase activity in the gills of the Pacific oyster Crassostrea gigas[J]. Environmental Toxicology, 2009, 25 4: 327-332. DOI: 10.1002/tox.20491
[2] J L TOWNSHEND  M C. Control of Pratylenchus penetrans and Meloidogyne hapla and Yield Response of Alfalfa Due to Oxamyl Seed Treatments.[J]. Journal of nematology, 1987, 19 4: 454-458.
[3] R C BAINES  R H S. Effects of oxamyl on the citrus nematode, Tylenchulus semipenetrans, and on infection of sweet orange.[J]. Journal of nematology, 1976, 8 2: 122-130.
[4] V. FAYEZ  W. W K. Acute toxic effects of oxamyl in the rat[J]. Fundamental and Applied Toxicology, 1992, 18 1: Pages 155-159. DOI: 10.1016/0272-0590(92)90209-z