23135-22-0

Oxamyl is a white crystalline solid. Sulfur or garlic-like odor. Molecular weight=219.3

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. Transport to the health care facility.

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2991 Carbamate pesticides, liquid, toxic, flammable, flash point ＜23°C, Hazard Class: 6.1; Labels: 6.1-Poisonous material, 3-Flammable liquid.

Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur).

Oxamyl, is also called N,N-dimethyl-2-methylcarbamoyloxyimino- 2-(methylthio)acetamide (IUPAC), consists of colorless crystals, which are readily soluble in water, methanol, ethanol, acetone, and fairly soluble in toluene. Oxamyl is produced by chlorination of the oxime of methylglycolate, reaction with methanethiol and alkali, and conversion to the carbamate with methyl isocyanate.

Consult with environmental regulatory agencies for guidance on acceptable disposal 2264 Oxamyl practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Small quantities may be treated with alkali and buried in a landfill. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Insecticide, nematocide, acaricide.

Oxamyl is a broad spectrum systemic insecticide/nematicide. It exhibits both oral and contact toxicity to control both sucking and chewing insects and mites in a wide variety of row crops, fruits, vegetables and ornamentals.

Oxamyl is a pesticide used in the treatment and protection of crops from parasites and insects.

ChEBI: Oxamyl is a carbamate ester. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a carbamate insecticide, an acaricide, an antinematodal drug and an agrochemical. It is functionally related to a methylcarbamic acid.

Insecticide, Nematicide, Acaricide: A systemic and contact insecticide/acaricide and nematicide, oxamyl is a restricted use pesticide used on apples, bananas, carrots, celery, citrus, cotton, cucumbers, eggplants, garlic, ginger, muskmelon (including cantaloupe and honeydew melon), onion (dry bulb), peanuts, pears, peppers, peppermint, pineapples, plantains, potatoes, pumpkins, soybeans, spearmint, squash, sweet potatoes, tobacco, tomatoes, watermelons, yams. Oxamyl is also used on non-bearing apple, cherry, citrus, peach, pear, and tobacco. It is applied directly onto plants or the soilsurface. It is available in both liquid and granular form, but the granular form is banned in the U.S. It has no residential use. Registered for use in EU countries[115

BLADE®; D-1410®; DPX 1410®; INSECTICIDE-NEMACIDE 1410®; OXAMYL CARBAMATE INSECTICIDE®; THIOXAMYL®; VYDATE®; VYDATE® 10G; VYDATE L®; VYDATE INSECTICIDE/NEMATICIDE®; VYDATE OXAMYL INSECTICIDE/NEMATOCIDE®[C]

Soil. Oxamyl rapidly degraded in a loamy sand and fine sand soil at 25°C to carbon dioxide and the intermediate methyl N-hydroxy-N,N-dimethyl-1-thiooxaminidate (Rajagopol et al., 1984). The reported half-life in soil is approximately one week (Worthing and Hance, 1991). Ou and Rao (1986) reported a half-life in soil of 8–50 days. The reported half-lives of oxamyl in Pitstone, Devizes, Sutton Veany and Mepal soils at 15°C were reported to be 10.2–13.1, 6.2, 7.1 and 17.8 days, respectively (Bromilow et al., 1980). Smelt et al. (1987) reported that oxamyl degraded at a higher rate in field plots after repeated applications of this nematocide than in soils that received no treatment. The repeated applications of oxamyl to soils probably induced microbial activity, which resulted in the accelerated disappearance of this compound.
Harvey and Han (1978) reported a half-life of 8 days for oxamyl in soil.
Groundwater. According to the U.S. EPA (1986) oxamyl has a high potential to leach to groundwater.
Plant. Dislodgable residues of oxamyl on cotton leaf 0, 24, 48, 72 and 96 hours after application (0.41 kg/ha) were 1.5, 1.1, 1.2, 0.85 and 0.76 mg/m2, respectively (Buck et al., 1980).
Chemical/Physical. The hydrolysis half-lives of oxamyl in a sterile 1% ethanol/water solution at 25°C and pH values of 4.5, 6.0, 7.0 and 8.0, were 300, 17, 1.6 and 0.20 weeks, respectively (Chapman and Cole, 1982). Under alkaline conditions, oxam

Oxamyl degrades in soils, plants and animals following common metabolic pathways. Primary degradation reactions include the hydrolysis of the carbamate ester to yield the corresponding oxyimidothioate and nitrile. Other major metabolic reactions include N-demethylation and the hydration/oxidation of the nitriles to the corresponding amides and acids. The majority of the oxamyl metabolites are recovered as conjugates in plants and animals. No metabolites containing the oxidised thiomethyl group were observed. The primary degradation/metabolic pathways of oxamyl are presented in Scheme 1.

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from heat and light. Where possible,automatically transfer material from drums or other storagecontainers to process containers.

Oxamyl (1) was stable under acidic conditions but hydrolysed rapidly under basic conditions at 25 °C with DT₅₀ values of >30 days at pH 5, 8 days at pH 7, and 3 hours at pH 9 (McNally and Wheeler, 1988). Cleavage of the methylcarbamoyl bond yielded methyl 2-( dimethylamino)- N-hydroxy-2-oxoethanimidothioate (2) as the primary hydrolysis product.
Exposure to artificial sunlight enhanced the degradation of oxamyl in pH 5 solution (DT₅₀ 7 vs. >30 days) to yield compound 2 (McNally, 1988). Rapid degradation of oxamyl was also observed in natural water exposed to natural sunlight (DT₅₀ <1 day, Harvey and Han, 1978a). Compound 2 and its geometrical isomer (3) were major products observed in natural and distilled water exposed to artificial and natural sunlight. Further hydrolysis yielded (dimethy1amino)oxoacetica cid (4) as a minor photodegradation product in natural water exposed to natural sunlight.