2468783-75-5

BAY-888 exhibits IC₅₀ value of 1.5 nM and 5.5 nM towards CSNK1A1 and CSNK1D, respectively.

BAY-888 is an orally active CSNK1A1 and CSNK1D inhibitor with IC50 of 1.5 nM and 5.5 nM, respectively. BAY-888 has antitumor activity[1][2].

[1] Volker Schulze, et al. Substituted pyrrolo-pyridinone derivatives and therapeutic uses thereof. WO2022023337 A1.
[2] Steven M. Corsello, et al Abstract 3588: Discovery of potent and selective CSNK1A1 inhibitors for solid tumor therapy. Cancer Res 15 June 2022; 82 (12_Supplement): 3588.