24677-86-9

Name	Lenperone
CAS	24677-86-9
Molecular Formula	C22H24ClF2NO2
MDL Number	MFCD01737494
Molecular Weight	407.89
MOL File	24677-86-9.mol

Synonyms

AHR-2277 Nsc303301 Lenperone HCl 4-[4-(4-fluorobenzoyl)piperidin-1-ium-1-yl]-1-(4-fluorophenyl)butan-1-one Butyrophenone, 4'-fluoro-4-[4-(p-fluorobenzoyl)piperidino]-, hydrochloride 1-Butanone, 4-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-(4-fluorophenyl)-, hydrochloride

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Hazard Information

Uses

Lenperone hydrochloride (AHR 2277) is an antipsychotic compound and a dopamine antagonist. Lenperone hydrochloride reduces gastroesophageal sphincter pressure of healthy dogs. Lenperone hydrochloride can be used for neurological disease research[1][2].

in vivo

Lenperone hydrochloride (0.16 and 0.44 mg/kg; intramuscular injection; once) decreases mean gastroesophageal sphincter pressure (GESP) of healthy dogs^[1]. Lenperone hydrochloride (0.5, 1.0 and 2.0 mg/kg; subcutaneous injection) shows antipsychotic effects with inducing a dose-dependently cataleptic state and reducing bilateral lesion of the nucleus interstitialis stria terminalis in rats with brain damage^[2].

Animal Model:	Healthy adult dogs^[1]
Dosage:	0.16 and 0.44 mg/kg
Administration:	Intramuscular injection; 0.16 and 0.44 mg/kg, once
Result:	Effectively decreased gastroesophageal sphincter pressure (GESP) of dogs.

References

[1] Johnson SE, et al. Effect of lenperone hydrochloride on gastroesophageal sphincter pressure in healthy dogs. Can J Vet Res. 1989 Apr;53(2):248-50. PMID:2565757
[2] Costall B, Naylor RJ. Mesolimbic involvement with behavioural effects indicating antipsychotic activity. Eur J Pharmacol. 1974 Jun;27(1):46-58. DOI:10.1016/0014-2999(74)90201-5

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TargetMol Chemicals Inc.

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