244192-94-7

L-748,337 is a selective competitive β3-adrenoceptor antagonist.

Competitive β 3 -adrenoceptor antagonist that displays selectivity over β 1 and β 2 receptors (K i values are 4.0, 204 and 390 nM for β 3 -, β 2 - and β 1 -adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC 50 = 6 nM).

Beta-3 adrenergic receptor: 4 nM (Ki); Beta-2 adrenergic receptor: 204 nM (Ki); Beta-1 adrenergic receptor: 390 nM (Ki)

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