239066-73-0

Name	5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene
CAS	239066-73-0
Molecular Formula	C23H25NO2
Molecular Weight	347.45
MOL File	239066-73-0.mol

Synonyms

AL438 AL-438 AL 438 5-Allyl-10-methoxy-2,2,4-trimethyl-2,4a,4b,5,10b,11,12,12a-octahydro-1H-6-oxa-1-aza-chrysene 1H-[1]Benzopyrano[3,4-f]quinoline, 2,5-dihydro-10-methoxy-2,2,4-trimethyl-5-(2-propen-1-yl)-

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Hazard Information

Description

AL-438 is a non-steroidal selective modulator for the glucocorticoid receptor (GR).

Uses

AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2].

in vivo

AL-438 (1, 10, 100 mg/kg; p.o.) shows anti-inflammatory activity in rats^[2].

Animal Model:	Male Sprague Dawley rats (carrageenan paw edema model)^[2]
Dosage:	1, 10, 100 mg/kg
Administration:	P.o.
Result:	Showed antiinflammatory activity with ED₅₀ value of 11 mg/kg in acute inflammation assay.

References

[1] Owen HC, et al. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. DOI:10.1016/j.mce.2006.11.006
[2] Coghlan MJ, et al. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9. DOI:10.1210/me.2002-0355

Supplier

Shanghai Changyan Chem & Tech Co., Ltd.

Telephone021-20242659 18930833303

Websitehttp://www.changyanchem.cn

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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