2376990-29-1

Thalidomide-4-O-C4-NH2 hydrochloride is a synthesized?E3 ligase ligand-linker conjugate?that incorporates the Thalidomide (HY-14658) based cereblon ligand and a linker used in PROTAC technology.

Cereblon

Store at -20°C

[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527