1957236-08-6

Name	1H-Isoindole-1,3(2H)-dione, 4-[(10-aminodecyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-
CAS	1957236-08-6
Molecular Formula	C23H31N3O5
Molecular Weight	429.51
MOL File	1957236-08-6.mol

Synonyms

Thalidomide-O-C10-NH2 Thalidomide-4-O-C10-NH2 4-[(10-Aminodecyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione 1H-Isoindole-1,3(2H)-dione, 4-[(10-aminodecyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-

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Chemical Properties

Boiling point	644.1±50.0 °C(Predicted)
density	1.234±0.06 g/cm3(Predicted)
pka	10.70±0.40(Predicted)

Hazard Information

Uses

Thalidomide-4-O-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024

Supplier

Daicel Chiral Technologies (China)CO.,LTD

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Jilin Province Woda Biotechnology Co., Ltd.

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Websitehttps://www.wodapro.com

ShenZhen Trendseen Biological Technology Co.,Ltd.

Telephone 13417589054

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList312717/0_EN.htm

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