ChemicalBook CAS DataBase List 2376-65-0

2376-65-0

Name	Fluphenazine decanoate dihydrochloride
CAS	2376-65-0
Molecular Formula	C32H45ClF3N3O2S
Molecular Weight	628.24
MOL File	2376-65-0.mol

Safety Data

RIDADR	UN 2811 6.1 / PGII
WGK Germany	3
HS Code	2934302300

Hazard Information

Uses

Fluphenazine decanoate dihydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Fluphenazine Decanoate
Fluphenazine Decanoate Injection

in vivo

Fluphenazine decanoate dihydrochloride (0.22 mg/kg and followed by 0.33 mg/kg; i.m.; 8 times every 3 weeks), as an antipsychotic, increases sensitivity to dopamine on monkey model following extended treatment^[2].
Fluphenazine decanoate dihydrochloride (25 mg/kg; i.m.; 6 times every 3 weeks; 24 weeks) induces mouth movements in the rat, serves as a pharmacological model of human tardive dyskinesia^[3].
Fluphenazine decanoate dihydrochloride (1, 2, 3 mg/kg/d; s.c.; 60 d) shows antifertility effects and induces hyperprolactinemia concomitant with gonadotropin suppression in adult male rat^[4].

Animal Model:	Cebus apella monkey^[2]
Dosage:	0.22 mg/kg and followed by 0.33 mg/kg
Administration:	Intramuscular injection; 8 times per 3 weeks; 0.22 mg/kg for 63 weeks and 0.33 mg/kg for 6 weeks
Result:	Decreased the aggressiveness composite behavioral variables (CBV). Resulted stereotypic behavior induced by agonist and decreased prolactin response to AMPH.

Animal Model:	Male Sprague-Dawley rats (250 g)^[3]
Dosage:	25 mg/kg
Administration:	Intramuscular injection into the hind limb; 24 weeks
Result:	Resulted in spontaneous vacuous chewing mouth movements and jaw tremor.

Animal Model:	Adult male rats^[4]
Dosage:	1, 2, 3 mg/kg/d
Administration:	Subcutaneous injection between 10:00-12:00 h; 60 days
Result:	Increased serum prolactin level and suppressed serum LH and FSH levels at day 60. Increased hypothalamic tyrosine hydroxylase levels, enhanced chromatin decondensation, and resulted DNA denaturation.

2376-65-0

Safety Data

Hazard Information

Uses

in vivo

IC 50

Supplier

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