Description
JWH 018 is a synthetic cannabinoid (CB) that potently activates the central CB
1 and peripheral CB
2 receptors (K
i = 9.0 and 2.94 nM, respectively).
1 This cannabimimetic compound has frequently been found in herbal blends.
2,3,4 JWH 018 N-
(4,5-
epoxypentyl) analog is distinguished by a terminal epoxide group on the alkyl chain. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic and research purposes.
References
1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Auw?rter, V., Dresen, S., Weinmann, W., et al. “Spice” and other herbal blends: Harmless incense or cannabinoid designer drugs? J. Mass Spectrom. 44(5),832-837(2009).
3. Lindigkeit, R., Boehme, A., Eiserloh, I., et al. Spice: A never ending story? Forensic Sci. Int. 191(1-3),58-63(2009).
4. Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al. Identification of a cannabimimetic indole as a designer drug in a herbal product Forensic Toxicol. 27,61-66(2009).
