ChemicalBook CAS DataBase List 23567-23-9

23567-23-9

Name	PROCYANIDIN B3
CAS	23567-23-9
Molecular Formula	C30H26O12
MDL Number	MFCD00166354
Molecular Weight	578.523
MOL File	23567-23-9.mol

Chemical Properties

Melting point	218-219℃
Boiling point	955.3±65.0 °C(Predicted)
density	1.705
storage temp.	?20°C
solubility	Soluble in acetone and acetonitrile
form	powder
pka	9.29±0.60(Predicted)
color	White
InChIKey	XFZJEEAOWLFHDH-AVFWISQGSA-N
SMILES	[C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2[C@@H](C2=C3O[C@H](C4=CC=C(O)C(O)=C4)[C@@H](O)CC3=C(O)C=C2O)[C@@H]1O
CAS DataBase Reference	23567-23-9

Safety Data

Hazard Codes	Xi
Risk Statements	36/37/38 less more
Safety Statements	26-36 less more

Hazard Information

Uses

Procyanidin B3 is a natural product that acts as a specific HAT inhibitor. Procyanidin B3 is a polyphenol flavonoid dimer of (+)-catechin with diverse biological properties. Procyanidin B3 is a dimeric flavanol and an antifungal phenol extracted from Woodfordia uniflora.

Definition

ChEBI: A proanthocyanidin consisting of two molecules of (+)-catechin joined by a bond between positions 4 and 8' in alpha-configuration. It can be found in red wine, in barley, in beer, in peach or in Jatropha macrantha, the Huanarp Macho.

in vivo

Procyanidin B3 (100 mg/kg, p.o., 5 days a week for 4 weeks) prevents articular cartilage degeneration and heterotopic cartilage formation in a surgically-induced osteoarthritis mice model^[2]. Procyanidin B3 (30 mg/kg, p.o., once daily for 4 weeks) delays the development of intervertebral disc degeneration (IVDD) in a Lipopolysaccharides (HY-D1056)-induced IVDD Sprague-Dawley rats model^[2].

Animal Model:	Lipopolysaccharides (HY-D1056)-induced IVDD (intervertebral disc degeneration) Sprague-Dawley rats model
Dosage:	30 mg/kg
Administration:	Oral gavage (p.o.),once daily for 4 weeks
Result:	Prevented the loss of gelatin NP cells and structural damage of annulus fibrosus in IVDD rat model.

Animal Model:	Surgically-induced osteoarthritis mice model^[2]
Dosage:	100 mg/kg
Administration:	Oral gavage (p.o.), once daily, 5 days a week for 4 weeks
Result:	Prevented aberrant articular cartilage degeneration and heterotopic cartilage formation through suppression of the nitric oxide synthase (iNOS).

IC 50

CBP/p300; TLR4

storage

Store at -20°C

Spectrum Detail

Supplier

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