2349367-89-9

NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763)-induced cell death[1][2].

NVS-ZP7-4 is a potent inhibitor of the Notch signaling pathway th at induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-4 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter th at increases ER zinc levels.

[1] Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188. DOI:10.1038/s41589-018-0200-7
[2] Chen PH, et al. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021 Feb 19;12(2):198. DOI:10.1038/s41419-021-03482-5