ChemicalBook CAS DataBase List 2348795-14-0

2348795-14-0

Name	Benzamide, N-cyclopentyl-3-[[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]-
CAS	2348795-14-0
Molecular Formula	C22H24N2O3
Molecular Weight	364.44
MOL File	2348795-14-0.mol

Chemical Properties

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Animal Model:	Liver fibrosis C57BL/6J mice induced by CCl₄^[1]
Dosage:	15 or 30 mg/kg
Administration:	Oral administration; daily; 3 weeks
Result:	Significantly prevented CCl₄-induced liver injury and reduced liver weight factor, serum ALT, AST, CHO and TG levels. Significantly improved structural damage and inflammatory cell infiltration in the liver, and reduced collagen deposition in liver tissue. Reduced accumulation of CCl₄-induced immune cells, such as hepatic macrophages (F4/80⁺ CD11b⁺), Th1 cells (CD69⁺ CD4⁺), and Th2 cells (CD69⁺ CD8⁺) so on.