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L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

ChEBI: L-ascorbic acid 2-phosphate is an aldonolactone phosphate that is the 2-phosphate ester of L-ascorbic acid. It can stimulate collagen formation. It is functionally related to a L-ascorbic acid. It is a conjugate acid of a L-ascorbate 2-phosphate(3-).

L-ascorbic acid 2-phosphate is a long-acting vitamin C derivative that stimulates collagen expression and formation. It can be used as a medium to supplement the osteogenic differentiation of human adipose stem cells (hASCs).

Human Endogenous Metabolite

[1] Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52(12):8711-7. DOI:10.1167/iovs.11-7592
[2] Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266(15):9997-10003. PMID:2033086
[3] Kyll?nen L, et al. Effects?of?different?serum?conditions?on?osteogenic?differentiation?of?human?adipose?stem cells?in vitro.Stem?Cell?Res Ther.?2013 Feb 15;4(1):17. DOI:10.1186/scrt165