2310286-45-2

IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active[1].

IDO1: 28 nM (IC₅₀); IDO2: 144 nM (IC₅₀)

[1] He X, et al. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021;64(24):17950-17968. DOI:10.1021/acs.jmedchem.1c01305