ChemicalBook CAS DataBase List 2308504-22-3

2308504-22-3

Name	[(3R)-3-Amino-1-piperidinyl][2-[1-[(4-fluorophenyl)methyl]-1H-indol-2-yl]-3-methylimidazo[1,2-a]pyridin-7-yl]methanone
CAS	2308504-22-3
Molecular Formula	C29H28FN5O
Molecular Weight	481.57
MOL File	2308504-22-3.mol

Chemical Properties

density	1.33±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
solubility	Acetonitrile: Slightly Soluble: 0.1-1 mg/ml DMSO: Slightly Soluble: 0.1-1 mg/ml
form	Solid
pka	9.54±0.20(Predicted)
color	Light yellow to yellow

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Animal Model:	LL2 tumor C57BL/6 mouse model; B16F10 tumor C57BL/6 mouse model
Dosage:	50 mg/kg
Administration:	Oral gavage (p.o.), twice daily
Result:	Led to a significant downregulation of CXCR2 receptor expression in Ly6G cells of the mice, while CXCR4 receptor expression remained unchanged. Had no effect on the cell counts of bone marrow cells, CD8 T cells, and NK cells in tumor-bearing mice model.