Description
Neurofibrillary tangle BODIPY (600/710 nm) is a fluorescent probe for neurofibrillary tangles (NFTs).1 It binds to tau-K18 aggregates in a cell-free assay (Kd = 16.8 nM) and is 2.17-fold selective for tau-K18 aggregates over amyloid-β (1-42) (Aβ42) aggregates. NFT BODIPY (600/710 nm) has been used to label NFTs in postmortem hippocampus from patients with Alzheimer’s disease. It has been used to identify tauopathy in vivo and ex vivo in transgenic human tauP301L-expressing mice with a lower signal occurring in the brain of wild-type mice. NFT BODIPY (600/710 nm) displays excitation maxima ranging from 570 to 600 nm and emission maxima ranging from 710 to 774 nm in the solvents methylene chloride, THF, methanol, DMSO, and PBS.WARNING This product is not for human or veterinary use.
