ChemicalBook CAS DataBase List 22594-69-0

22594-69-0

Name	DICHLOROTRICARBONYLRUTHENIUM (II) DIMER
CAS	22594-69-0
Molecular Formula	C6Cl4O6Ru2
MDL Number	MFCD00011528
Molecular Weight	512.01
MOL File	22594-69-0.mol

Chemical Properties

Appearance	Off-white to slightly yellow powder
Melting point	208°C (dec.)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Soluble in DMSO
form	crystal
color	off-white
Water Solubility	Insoluble in water
InChIKey	JYHHJVKGDCZCCL-UHFFFAOYSA-J

Safety Data

Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38 less more
Safety Statements	26-37/39 less more
RIDADR	UN3466
WGK Germany	3
HazardClass	6.1
PackingGroup	III

Hazard Information

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Animal Model:	Acute I/R gastric lesions treated male Wistar rats (250-300 g)^[3]
Dosage:	1, 5 or 10 mg/kg
Administration:	Oral gavage (i.g.); single dose
Result:	Significantly decreased the area of I/R gastric damage and significantly increased GBF at doses of 1 or 5 mg/kg. Significantly increased mRNA expression of HMOX-1 but not HMOX-2 in gastric mucosa and significantly increased blood concentration at dose of 5 mg/kg. Significantly increased gastric mucosal PGE2 content at dose of 5 mg/kg. Significantly decreased mRNA expression of iNOS but not eNOS in gastric mucosa at dose of 5 mg/kg. Significantly decreased 8-hydroxyguanozine (8-OHG) concentration in gastric mucosa at dose of 5 mg/kg. Decreased the expression of pro- and anti-inflammatory markers' mRNA and proteins at dose of 5 mg/kg.

22594-69-0

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