22581-06-2

Name	3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]benzaldehyde
CAS	22581-06-2
MOL File	22581-06-2.mol

Synonyms

Ilicicolin A 3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]benzaldehyde

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Safety Data

Toxicity

LD50 intraperitoneal in mouse: > 100mg/kg

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Hazard Information

Uses

Ilicicolin A is a potent anticancer agent. Ilicicolin A induces apoptosis. Ilicicolin A inhibits cell growth and colony formation. Ilicicolin A shows antitumor activity. Ilicicolin A has the potential for the research of prostate cancer[1].

in vivo

Ilicicolin A (10 mg/kg; i.p.; six times a week for 3 weeks) inhibits tumor growth in mice^[1].

Animal Model:	Four-week-old, 18 g, male NOD/SCID mice (22Rv1 cells) ^[1]
Dosage:	10 mg/kg
Administration:	I.p.; six times a week for 3 weeks
Result:	Suppressed tumor growth but did not elicit a significant effect on bodyweight.

References

[1] Guo L, et al. Ilicicolin A Exerts Antitumor Effect in Castration-Resistant Prostate Cancer Via Suppressing EZH2 Signaling Pathway. Front Pharmacol. 2021 Oct 27;12:723729. DOI:10.3389/fphar.2021.723729

Supplier

Zhejiang Huida Biotech Co., LTD

Telephone0571-89903022 18679456698

Websitehttps://www.huidacollection.cn

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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