ChemicalBook CAS DataBase List 2253947-47-4

2253947-47-4

Name	Urea, N-[(3S,4R)-4-(2,6-difluoro-4-methoxyphenyl)-2-oxo-3-pyrrolidinyl]-N'-phenyl-
CAS	2253947-47-4
Molecular Formula	C18H17F2N3O3
Molecular Weight	361.34
MOL File	2253947-47-4.mol

Chemical Properties

Boiling point	499.4±45.0 °C(Predicted)
density	1.37±0.1 g/cm3(Predicted)
form	Solid
pka	10.24±0.40(Predicted)
color	White to off-white

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Animal Model:	Male C57BL/6 mice^[1]
Dosage:	0.3 mg/kg
Administration:	P.o.; daily for 24 days
Result:	Left ventricle (LV) chamber remodeling is attenuated after myocardial infarction (MI). Reduced infarct length by 39% relative to vehicle.

Animal Model:	Male mice (BALB/cCrSlc)^[1]
Dosage:	1 mg/kg
Administration:	P.o. (Pharmacokinetic Analysis)
Result:	The C_max, T_1/2, AUC_0-inf, and bioavailability (BA) values were 160 nmol/L, 0.68 hours, 120 nmol/L?h, and 24%, respectively.

2253947-47-4

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