2253733-09-2

GSK9311 hydrochloride, a less active analogue of GSK6853, can be used as a negative control. GSK9311 hydrochloride inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].

BRPF1: 6.0 (pIC₅₀); BRPF2: 4.3 (pIC₅₀)

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[1] Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7. DOI:10.1021/acsmedchemlett.6b00092