2251806-70-7

Name	Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-, (3S)-, (2E)-2-butenedioate (1:1)
CAS	2251806-70-7
Molecular Formula	C15H17F2NO5
Molecular Weight	329.3
MOL File	2251806-70-7.mol

Synonyms

Pyrrolidine, 3-(2,3-difluorophenyl)-3-methoxy-, (3S)-, (2E)-2-butenedioate (1:1)

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Chemical Properties

storage temp.	4°C, away from moisture
solubility	DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)
form	Solid
color	White to off-white

Hazard Information

Uses

Pirepemat (IRL752) fumarate is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat fumarate is used for the study of Parkinson's disease[1][2].

Biological Activity

Pirepemat (IRL752) fumarate is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat fumarate is used for the study of Parkinson's disease[1][2]. IRL752 fumarate displays its highest in vitro affinities for 5-HT and NA-related targets[2]. IRL752 (3.7-100 μmol/kg, s.c.) fumarate has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reverses deficits resulting from hypomonoaminergic function[2].

in vivo

IRL752 (3.7-100 μmol/kg, s.c.) fumarate has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reverses deficits resulting from hypomonoaminergic function^[2].

Animal Model:	Normal rats^[2]
Dosage:	3.7-100 μmol/kg
Administration:	S.c., 30 min prior to testing
Result:	Induced dose-dependent and regio-selective alterations in brain monoamine transmission indices and gene expression.

References

[1]. Ipsen and IRLAB Enter Exclusive Worldwide Licensing Agreement Aimed to Improve the Lives of People Living with Parkinson's Disease. [2]. S Hjorth, et al. (3 S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) -a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419.

Supplier

Guangzhou Younan Technology Co., Ltd

Telephone020-82000279 18988941452

Websitehttp://www.ubiochem.cn/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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