2245072-20-0

LIT-001 is the first potent nonpeptide agonist of oxytocin receptor (OT-R).

LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM). LIT-001 free base improves social interaction in a mouse model of autism[1].

[1] Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692. DOI:10.1021/acs.jmedchem.8b00697