2243076-67-5

ZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM[1].

BRD4: 5 nM (DC₅₀, 5 hours of treatment); Cereblon

Store at -20°C, stored under nitrogen

[1] Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14(7):706-714. DOI:10.1038/s41589-018-0055-y