22356-89-4

The general procedure for the synthesis of 2-amino-N-methylacetamide from compound 12a (CAS:21855-72-1) was as follows: 10% Pd/C catalyst was added to a methanol (10 mL) solution of compound 12a (170 mg, 0.77 mmol). The hydrogenation reaction was carried out at room temperature and atmospheric pressure for 3 hours. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the resulting clarified solution was dried to give 2-amino-N-methylacetamide as an oily product. The yield was 97%. The molecular formula is C3H9N2O.

[1] Patent: WO2006/103463, 2006, A1. Location in patent: Page/Page column 15; Figure 3
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 3, p. 1285 - 1297
[3] Journal of Organic Chemistry, 1977, vol. 42, # 12, p. 2105 - 2108
[4] Synthesis, 1977, p. 478 - 480