223104-29-8

SEA0400 is a selective inhibitor of the Na⁺/Ca²⁺ exchanger (IC₅₀s = 5, 8.3, and 33 nM for inhibiting Na⁺-dependent Ca²⁺ uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively). It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson''s disease and to attenuate reperfusion injury in both in vitro and in vivo cerebral ischemic models.

SEA 0400 is a novel and selective inhibitor of Na+-Ca2+ exchanger.

Na+-Ca2+ exchanger

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[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] TETSUAKI NASHIDA . The specific Na+/Ca2+ exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells[J]. Neurochemistry international, 2011, 59 1: Pages 51-58. DOI: 10.1016/j.neuint.2011.03.026
[3] YUKIO AGO . SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson’s disease[J]. Neuropharmacology, 2011, 61 8: Pages 1441-1451. DOI: 10.1016/j.neuropharm.2011.08.041