2230821-40-4

SJF 1521 is a selective EGFR PROTAC?? Degrader based on the EGFR inhibitor lapatinib linked to a von Hippel-Lindau (VHL) recruiting ligand by PEG3. SJF 1521 exhibits selectivity for EGFR, including mutant forms, over HER2 and induces degradation of EGFR in OVCAR8 cells.

SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells[1].

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[1] Burslem GM,et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3. DOI:10.1016/j.chembiol.2017.09.009