2225887-26-1

EGFR-IN-5 is a EGFR inhibitor with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.

EGFR: 10.4 nM (IC₅₀); EGFR^L858R: 1.1 nM (IC₅₀); EGFR^L858R/T790M: 34 nM (IC₅₀); EGFR^{L858R/T790M/C797S}: 7.2 nM (IC₅₀)

[1] Zhang H, et al. Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs. Eur J Med Chem. 2018 Mar 25;148:221-237. DOI:10.1016/j.ejmech.2018.02.051