22237-13-4

White crystalline powder

suzuki reaction

Reactant involved in Suzuki cross coupling reactions
Reactant involved in the synthesis of biologically active molecules including:
Novel modulators of survival motor neuron protein for treatment of spinal muscular atrophy
Amino-trimethoxyphenyl-aryl thiazoles for use as microtubule inhibitors and antitumor agents
Bicyclic hydroxyphenyl methanone derivatives for use as hydroxysteroid dehydrogenase inhibitors
Dual immunosuppressive and anti-inflammatory agents
Antiproliferatives via Suzuki cross-coupling / amination reactions

A hexane solution of butyllithium (30 mL, 1.58 M, 47 mmol) was added dropwise to a THF solution (50 mL) of 2-bromo-α,α-trifluorotoluene (9.79 g, 43.5 mmol) at -78° C. The aryllithium was then transferred to a THF solution of B(OEt)3 (30 mL, 176 mmol) by c