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98-80-6

Name Phenylboronic acid
CAS 98-80-6
EINECS(EC#) 202-701-9
Molecular Formula C6H7BO2
MDL Number MFCD00002103
Molecular Weight 121.93
MOL File 98-80-6.mol
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Chemical Properties

Appearance white to light yellow crystal powder
Melting point  216-219 °C(lit.)
Boiling point  265.9±23.0 °C(Predicted)
density  1.13±0.1 g/cm3(Predicted)
storage temp.  0-6°C
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form  Crystalline Powder
pka 8.83(at 25℃)
color  White to off-white
Water Solubility  10 g/L (20 ºC)
Sensitive  Hygroscopic
Detection Methods HPLC,NMR
Merck  14,1068
BRN  970972
Stability: Hygroscopic
InChIKey HXITXNWTGFUOAU-UHFFFAOYSA-N
Uses
Phenyihoronic acid and its derivatives form complexes with polyol compounds such as saccharides and poly(vinyl alcohol) (PVA). Glucose-sensitive hydrogels can be prepared by using phenylhoronic acid as a ligand for target glucose. For example. a copolymer with phenylboronic acid moieties was synthesized by copolymerization of 4V-vinyl-2-pyrrolidone (NVP) and 3-(acryl- amide)phcnylhoronic acid (PBA). The complexes between the NVP-PBA copolymer and PVA enable us to construct glucose-sensitive insulin release systems because the complexes dissociated in response to the glucose concentration.
This phenylboronic acid is soluble in water and the coupling reaction can even be carried out in water. It is compatible with many organic substituents such as esters, ketones, alcohols, etc. which would prohibit the use of Grignard reagents in coupling reactions.
CAS DataBase Reference 98-80-6(CAS DataBase Reference)
EPA Substance Registry System 98-80-6(EPA Substance)
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Safety Data

Hazard Codes  Xn,Xi,N
Risk Statements 
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Statements 
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
WGK Germany  3
RTECS  CY8575000
Hazard Note  Harmful
TSCA  Yes
HazardClass  IRRITANT, MOISTURE SENSITIVE
HS Code  29310095
Toxicity
LD50 orl-rat: 740 mg/kg 14KTAK -,693,64

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