JH-VIII-49 (compound 10) is a potent and selective CDK8 inhibitor (IC50=16 nM) with excellent biological activity. JH-VIII-49 promotes CDK8 inhibition through its steroid backbone design. JH-VIII-49 can be used in the synthesis of PROTAC as a target protein ligand of JH-XI-10-02 (HY-111518)[1][2].
IC 50
CDK8: 16 nM (IC50)
References
[1] Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8
