220798-52-7

The general procedure for the synthesis of 3-(bromomethyl)benzene-1-sulfonamide from 3-(hydroxymethyl)benzene-1-sulfonamide was as follows: 1.48 g (7.90 mmol) of 3-(hydroxymethyl)benzene-sulfonamide was suspended in 25 mL of dichloromethane, and 2.35 g (8.69 mmol) of phosphorus tribromide was slowly added at 20°C. The reaction mixture was stirred overnight at room temperature. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction was quenched by careful addition of water and the organic phase was separated. The aqueous phase was extracted twice with dichloromethane. All organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. 1.9 g (94% yield) of 3-bromomethylbenzenesulfonamide crude product was obtained, which was pure enough to be used directly in the subsequent reaction.

[1] Patent: WO2015/7668, 2015, A1. Location in patent: Page/Page column 144
[2] Patent: EP1679069, 2006, A1. Location in patent: Page/Page column 92